Crosspovidone XL-10, also known as Polyplasdone XL-10 (PVPPXL-10), is a fine-particle-sized form of crosslinked povidone with a particle size of approximately 25 to 40 micrometers. It exhibits a popcorn-like structure and possesses a larger specific surface area and porosity compared to microcrystalline cellulose, contributing to its excellent water absorption and retention capabilities. Here is an overview of its applications in various fields:
Medical Field
- Pharmaceutical Excipients: XL-10 serves as a disintegrant in pharmaceutical formulations. It can rapidly absorb water and swell, causing tablets or capsules to disintegrate quickly, which facilitates drug release and absorption.
- Adsorbent and Carrier: Due to its large specific surface area and porosity, XL-10 can adsorb drugs, active ingredients, and other excipients. It can also act as a carrier to enhance drug stability and bioavailability.
- Suspending Agent and Thickener: In suspensions and pastes, XL-10 can increase the viscosity of the system, improving the stability of suspensions and preventing drug sedimentation.
- Controlled and Sustained Release: By adjusting the molecular weight, crosslinking degree, and other properties of XL-10, drug formulations with controlled and sustained release effects can be prepared, extending the duration of drug action.
Industrial Field
- Adhesives and Coatings: XL-10 can be used in the preparation of adhesives and coatings due to its excellent adhesion properties and mechanical performance. It can bond to various materials with high strength and function effectively in complex environments.
Food Field
- Food Additives: XL-10 can be used as a food additive due to its excellent stability and thickening properties. It can be used in the preparation of various special-purpose foods.
Other Applications
- Oral Formulations: XL-10 is widely used in oral formulations such as tablets, capsules, suspensions, and granules. It can improve the disintegration and dissolution properties of drugs, enhancing their absorption and bioavailability.
- Injectable Formulations: In injectable formulations, XL-10 can serve as a suspending agent or thickener, increasing the stability and rheological properties of the formulation.
- Ophthalmic Formulations: XL-10 can be used in ophthalmic formulations such as eyedrops and eye ointments to increase drug viscosity and residence time, thereby enhancing efficacy.
In summary, Crospovidone XL-10 demonstrates versatility across multiple fields due to its unique properties. Its applications span from pharmaceutical excipients and food additives to industrial adhesives and coatings, making it a highly valued material in various industries.
Audited Supplier 
){kind=link}